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Boscartins L-O: Cembrane-type Diterpenoids From the Gum Resin of Boswellia Sacra Flueck

Jiajia Wang, Bo Zhen, Jiawen Hu, Mengjiao Shi, Canjing Wei, Xue Wang, Hua Sun, Tengfei Ji

Phytochemistry. 2019 Jul;163:126-131.

PMID: 31059964

Abstract:

Four undescribed cembrane-type diterpenoids, boscartins L-O, as well as five known compounds (1S, 3R, 11S, 12R, 7E)-1,12-epoxy-4-methylenecembr-7- ene- 3,11-diol, isoincensole oxide, incensole oxide, incensole acetate and incensole oxide acetate were isolated from the gum resin of Boswellia sacra Flueck. (Burseraceae). The structures of these compounds were elucidated by extensive 1D and 2D NMR spectroscopic and mass spectrometric analysis, as well as comparisons with known compounds. The absolute configurations of the known compound (1S, 3R, 7E, 11S, 12R)-1,12-epoxy-4-methylenecembr-7-ene-3,11-diol was unequivocally confirmed by single-crystal X-ray diffraction analysis with Cu Kα radiation. Incensole acetate exhibited significant hepatoprotective activity at 10 μM against paracetamol-induced HepG2 cell damage.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP34701536 Incensole acetate Incensole acetate 34701-53-6 Price
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