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Bovine Milk-Derived α-lactalbumin Inhibits Colon Inflammation and Carcinogenesis in Azoxymethane and Dextran Sodium Sulfate-Treated Mice

Bovine Milk-Derived α-lactalbumin Inhibits Colon Inflammation and Carcinogenesis in Azoxymethane and Dextran Sodium Sulfate-Treated Mice

Makoto Yamaguchi, Shoko Takai, Akira Hosono, Taiichiro Seki

Biosci Biotechnol Biochem. 2014;78(4):672-9.

PMID: 25036966

Abstract:

Cyclooxygenase-2 is expressed early in colon carcinogenesis and plays crucial role in the progress of the disease. Recently, we found that α-lactalbumin had anti-inflammatory activity by inhibiting cyclooxygenase-2. In experiment 1, we investigated the effects of α-lactalbumin on the colon carcinogenesis initiated with azoxymethane (AOM) followed by promotion with dextran sodium sulfate (DSS) in mice. Dietary treatment with α-lactalbumin decreased fecal occult blood score at 3 days after DSS intake. α-Lactalbumin also decreased the colon tumor at week 9. In experiment 2, AOM-treated mice were sacrificed at 7 days after DSS intake. The plasma and colon prostaglandin E2 (PGE2) levels in AOM/DSS-treated mice were higher than those in the DSS-treated mice without initiation by AOM. α-Lactalbumin decreased PGE2 in both plasma and colon. These results suggest that α-lactalbumin effectively inhibited colon carcinogenesis, and the inhibition may be due to the decreased PGE2 by inhibiting cyclooxygenase-2 at cancer promotion stages.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9051290-B	α-Lactalbumin from bovine milk		9051-29-0	Price

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