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Broad-spectrum Antiviral Properties of Andrographolide

Swati Gupta, K P Mishra, Lilly Ganju

Arch Virol. 2017 Mar;162(3):611-623.

PMID: 27896563

Abstract:

Andrographolide, a diterpenoid, is known for its anti-inflammatory effects. It can be isolated from various plants of the genus Andrographis, commonly known as 'creat'. This purified compound has been tested for its anti-inflammatory effects in various stressful conditions, such as ischemia, pyrogenesis, arthritis, hepatic or neural toxicity, carcinoma, and oxidative stress, Apart from its anti-inflammatory effects, andrographolide also exhibits immunomodulatory effects by effectively enhancing cytotoxic T cells, natural killer (NK) cells, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC). All these properties of andrographolide form the foundation for the use of this miraculous compound to restrain virus replication and virus-induced pathogenesis. The present article covers antiviral properties of andrographolide in variety of viral infections, with the hope of developing of a new highly potent antiviral drug with multiple effects.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP5508587-A Andrographolide Andrographolide 5508-58-7 Price
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