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Broadly Applicable Ytterbium-Catalyzed Esterification, Hydrolysis, and Amidation of Imides

Céline Guissart, Andre Barros, Luis Rosa Barata, Gwilherm Evano

Org Lett. 2018 Sep 7;20(17):5098-5102.

PMID: 30130122

Abstract:

An efficient, broadly applicable, operationally simple, and divergent process for the transformation of imides into a range of carboxylic acid derivatives under mild conditions is reported. By simply using catalytic amounts of ytterbium(III) triflate as a Lewis acid promoter in the presence of alcohols, water, amines, or N, O-dimethylhydroxylamine, a broad range of imides is smoothly and readily converted to the corresponding esters, carboxylic acids, amides, and Weinreb amides in good yields. This method notably enables an easy cleavage of oxazolidinone-based auxiliaries.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP7440644 Ytterbium Ytterbium 7440-64-4 Price
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