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Bupropion Hydrochloride

Bupropion Hydrochloride

S R Khan, R T Berendt, C D Ellison, A B Ciavarella, E Asafu-Adjaye, M A Khan, P J Faustino

Profiles Drug Subst Excip Relat Methodol. 2016;41:1-30.

PMID: 26940167

Abstract:

Bupropion hydrochloride is a norepinephrine-dopamine disinhibitor (NDDI) approved for the treatment of depression and smoking cessation. Bupropion is a trimethylated monocyclic phenylaminoketone second-generation antidepressant, which differs structurally from most antidepressants, and resides in a novel mechanistic class that has no direct action on the serotonin system. Comprehensive chemical, physical, and spectroscopic profiles are presented. This analytical profile provides an extensive spectroscopic investigation utilizing mass spectrometry, one- and two-dimensional NMR, solid-state NMR, IR, NIR, Raman, UV, and X-ray diffraction. The profile also includes significant wet chemistry studies for pH, solubility, solution, and plasma stability. Both HPLC and UPLC methodology are presented for bupropion and its related impurities or major metabolites. The profile concludes with an overview of biological properties that includes toxicity, drug metabolism, and pharmacokinetics.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP31677937-A	Bupropion hydrochloride solution		31677-93-7	Price

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