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Buscopan Labeled With carbon-14 and Deuterium

Bachir Latli, Michael Stiasni, Matt Hrapchak, Zhibin Li, Nelu Grinberg, Heewon Lee, Carl A Busacca, Chris H Senanayake

J Labelled Comp Radiopharm. 2016 Nov;59(13):557-564.

PMID: 27753138

Abstract:

Hyosine butyl bromide, the active ingredient in Buscopan, is an anticholinergic and antimuscarinic drug used to treat pain and discomfort caused by abdominal cramps. A straightforward synthesis of carbon-14- and deuterium-labeled Buscopan was developed using scopolamine, n-butyl-1-14 C bromide, and n-butyl-2 H9 bromide, respectively. In a second carbon-14 synthesis, the radioactive carbon was incorporated in the tropic acid moiety to follow its metabolism. Herein, we describe the detailed preparations of carbon-14- and deuterium-labeled Buscopan.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP13536599-B Deuterium bromide Deuterium bromide 13536-59-9 Price
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