Home
Resources
Publications
Caffeine and the Analog CGS 15943 Inhibit Cancer Cell Growth by Targeting the Phosphoinositide 3-kinase/Akt Pathway

Caffeine and the Analog CGS 15943 Inhibit Cancer Cell Growth by Targeting the Phosphoinositide 3-kinase/Akt Pathway

Charlotte E Edling, Federico Selvaggi, Ragheda Ghonaim, Tania Maffucci, Marco Falasca

Cancer Biol Ther. 2014 May;15(5):524-32.

PMID: 24521981

Abstract:

Caffeine is a naturally occurring methylxanthine that acts as a non-selective adenosine receptor antagonist. Epidemiological studies demonstrated habitual coffee drinking to be significantly associated with liver cancer survival. We aimed to investigate the effects of caffeine and its analog CGS 15943 on hepatocellular carcinoma (HCC) and pancreatic cancer adenocarcinoma (PDAC). We demonstrate that caffeine and CGS 15943 block proliferation in HCC and PDAC cell lines by inhibiting the PI3K/Akt pathway. Importantly a kinase profiling assay reveals that CGS 15943 targets specifically the catalytic subunit of the class IB PI3K isoform (p110γ). These data give mechanistic insight into the action of caffeine and its analogs and they identify these compounds as promising lead compounds to develop drugs that can specifically target this PI3K isoform whose key role in cancer progression is emerging.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP104615181	CGS-15943		104615-18-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: