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Calpain Inhibitor I Reduces the Development of Acute and Chronic Inflammation

Calpain Inhibitor I Reduces the Development of Acute and Chronic Inflammation

S Cuzzocrea, M C McDonald, E Mazzon, D Siriwardena, I Serraino, L Dugo, D Britti, G Mazzullo, A P Caputi, C Thiemermann

Am J Pathol. 2000 Dec;157(6):2065-79.

PMID: 11106579

Abstract:

There is limited evidence that inhibition of the activity of the protease calpain I reduces inflammation. Here we investigate the effects of calpain inhibitor I in animal models of acute and chronic inflammation (carrageenan-induced pleurisy and collagen-induced arthritis). We report here for the first time that calpain inhibitor I (given at 5, 10, or 20 mg/kg i.p. in the pleurisy model or at 5 mg/kg i.p every 48 hours in the arthritis model) exerts potent anti-inflammatory effects (eg, inhibition of pleural exudate formation, mononuclear cell infiltration, delayed the development of the clinical signs and histological injury) in vivo. Furthermore, calpain inhibitor I reduced (1) the staining for nitrotyrosine and poly (ADP-ribose) polymerase (immunohistochemistry) and (2) the expression of inducible nitric oxide synthase and cyclooxygenase-2 in the lungs of carrageenan-treated rats and in joints from collagen-treated rats. Thus, prevention of the activation of calpain I reduces the development of acute and chronic inflammation. Inhibition of calpain I activity may represent a novel therapeutic approach for the therapy of inflammation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP110044821-B	Calpain Inhibitor I		110044-82-1	Price

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