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Can 14-3-3 Proteins Serve as Therapeutic Targets for the Treatment of Metabolic Diseases?

Can 14-3-3 Proteins Serve as Therapeutic Targets for the Treatment of Metabolic Diseases?

Kadidia Diallo, Abel K Oppong, Gareth E Lim

Pharmacol Res. 2019 Jan;139:199-206.

PMID: 30453034

Abstract:

Since their initial characterization as abundant brain proteins more than 5 decades ago, a resurgence into understanding the cellular functions of 14-3-3 proteins has emerged. While one of the earliest functions attributed to this eukaryotic scaffold protein family was the activation of enzymes involved in catecholamine and serotonin biosynthesis, 14-3-3 proteins have since been implicated in the regulation of several cellular processes including cell-cycle control, apoptosis, and metabolism. Moreover, increasing lines of evidence demonstrate links between changes in 14-3-3 protein function and the pathogenesis of chronic diseases. As a result, this has raised the question of whether 14-3-3 proteins represent viable targets for pharmacological intervention against diseases such as obesity, diabetes and cancer. In addition to providing an overview of the 14-3-3 protein family, we will discuss their connections to metabolism and metabolic diseases. We will also elaborate on the potential of targeting 14-3-3 proteins, as well as components of their interactomes, for developing novel therapies for treating metabolic diseases, including diabetes and obesity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
ALP853220527	CID 11210285 hydrochloride		853220-52-7 (free base)	Price

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