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Canine Pancreatic Islet Cell Tumours Secreting Insulin-Like Growth Factor Type 2: A Rare Entity

Canine Pancreatic Islet Cell Tumours Secreting Insulin-Like Growth Factor Type 2: A Rare Entity

R Finotello, L Ressel, M Arvigo, G Baroni, V Marchetti, G Romanelli, R Burrow, D Mignacca, L Blackwood

Vet Comp Oncol. 2016 Jun;14(2):170-80.

PMID: 24428588

Abstract:

Insulin-like growth factor type II (IGF-II) is the main cause of non-islet cell tumour hypoglycaemia (NICTH) and insulin is thought to be the only factor causing hypoglycaemia in insulinomas. However, two case reports of pancreatic neuroendocrine tumours (PNETs) producing IGF-II have been previously published: a human and a canine patient. In this study, we investigated clinical, histopathological, immunohistochemical and ultrastructural features, and biological behaviour of canine pancreatic IGF-II-omas, a subgroup of PNETs that has not been previously characterized. Case records of 58 dogs with confirmed PNETs and hypoglycaemia were reviewed: six patients were affected by IGF-II-omas. Surgery was performed in all cases and two dogs had metastases. Four patients remained alive and in remission at 370, 440, 560 and 890 days post-diagnosis; two died of non-tumour-related causes. IGF-II-omas can be differentiated from insulinomas through hypoinsulinaemia, IGF-II positive and insulin negative immunostaining. The prevalence of this neoplasia is low, accounting for just 6% of PNETs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248605	Insulin-like Growth Factor-II human			Price

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