Home
Resources
Publications
Capreomycin Inhalable Powders Prepared With an Innovative Spray-Drying Technique

Capreomycin Inhalable Powders Prepared With an Innovative Spray-Drying Technique

Aurélie Schoubben, Stefano Giovagnoli, Maria Cristina Tiralti, Paolo Blasi, Maurizio Ricci

Int J Pharm. 2014 Jul 20;469(1):132-9.

PMID: 24747443

Abstract:

The aim of the work was to produce inhalable capreomycin powders using a novel spray-drying technology. A 2(3) factorial design was used to individuate the best working conditions. The maximum desirability was identified at the smallest mean volume diameter (dv) and span, and the highest yield. Powders were characterized for size, morphology, flowability and aerodynamic properties. Mathematical models showed a good predictivity with biases lower than 20%. The maximum conformity with desirability criteria was obtained spraying a 10mg/mL bacitracin solution at 111 °C with the 4 μm pore size membrane. By processing capreomycin sulfate with the parameters optimized for bacitracin, an inhalable powder was obtained (i.e., yield of 82%, dv of 3.83 μm, and span of 1.04). By further optimization, capreomycin sulfate powder characteristics were improved (i.e., yield, ∼71%; dv, 3.25 μm; span, 0.95). After formulation with lactose, emitted dose and respirable fraction of 87% and ∼27% were obtained, respectively. Two capreomycin sulfate powders with suitable properties for inhalation were produced using the nano spray-dryer B-90.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1405374-A	Capreomycin Sulfate		1405-37-4	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: