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Capsiate Treatment in Liver Surgeries May Compromise Its Recovery

Pedro Paulo Barros, Gisele Mara Silva Gonçalves, Gustavo Henrique da Silva, Maria Clara Villaça Dias Bastos, Loren Nogaroto Ramos, Marilia Marinello Fernandes

Acta Cir Bras. 2018 May;33(5):439-445.

PMID: 29924209

Abstract:

Purpose:
To investigate the effects of capsiate treatment on hepatic hyperplasia in partially hepatectomized rats.
Methods:
The animals were divided into a Capsiate group (CPH), a Capsiate Post-Partial Hepatectomy group (CPPH) and a Partial Hepatectomy Control group (PH). CPH and CPPH animals received 60 mg/kg/day Capsiate for 30 days. Next, the rats underwent partial hepatectomy. CPPH animals continued to receive treatment for 48 h after partial hepatectomy. Liver tissue and intracardiac blood samples were obtained 24 or 48 h after PH.
Results:
Capsiate treatment interfered with hepatic parameters, reducing the number of mitoses and apoptosis and increasing blood ALT and alkaline phosphatase concentrations.
Conclusion:
Capsiate treatment preceding hepatic surgery may compromise the initial period of postoperative recovery.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP205687010 Capsiate Capsiate 205687-01-0 Price
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