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Carbamazepine Ozonation Byproducts: Toxicity in Zebrafish ( Danio rerio) Embryos and Chemical Stability

Carbamazepine Ozonation Byproducts: Toxicity in Zebrafish ( Danio rerio) Embryos and Chemical Stability

Johannes Pohl, Oksana Golovko, Gunnar Carlsson, Johan Eriksson, Anders Glynn, Stefan Örn, Jana Weiss

Environ Sci Technol. 2020 Mar 3;54(5):2913-2921.

PMID: 31990190

Abstract:

Carbamazepine (CBZ) is an anticonvulsant medication with highly persistent properties in the aquatic environment, where it has the potential to affect nontarget biota. Because CBZ and many other pharmaceuticals are not readily removed in conventional sewage treatment plants (STP), additional STP effluent treatment technologies are being evaluated and implemented. Whole effluent ozonation is a prospective method to remove pharmaceuticals such as CBZ, yet knowledge on the toxicity of CBZ ozonation byproducts (OBPs) is lacking. This study presents, for the first time, in vivo individual and mixture toxicity of four putative OBPs, that is, carbamazepine 10,11-epoxide, 10,11-Dihydrocarbamazepine, 1-(2-benzaldehyde)-4-hydro-(1H,3H)-quinazoline-2-one (BQM), and 1-(2-benzaldehyde)-(1H,3H)-quinazoline-2,4-dione (BQD) in developing zebrafish (Danio rerio) embryos. BQM and BQD were isolated from the ozonated solution as they were not commercially available. The study confirmed that the OBP mixture caused embryotoxic responses comparable to that of ozonated CBZ. Individual compound embryotoxicity assessment further revealed that BQM and BQD were the drivers of embryotoxicity. OBP chemical stability in ozonated CBZ water solution during 2 week dark storage at 22 °C was also assessed. The OBP concentrations remained over time, except for BQD which decreased by 94%. Meanwhile, ozonated CBZ persistently induced embryotoxicity over 2 week storage, potentially illustrating environmental concern.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS27508	Carbamazepine-10,11-epoxide-13C6 solution			Price

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