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Carbazolothiophene-2-carboxylic Acid Derivatives as Endothelin Receptor Antagonists

Govindarajulu Babu, Hui-Ming Yu, Shyh-Ming Yang, Jim-Min Fang

Bioorg Med Chem Lett. 2004 Mar 8;14(5):1129-32.

PMID: 14980650

Abstract:

The SmI(2)-promoted three-component coupling reaction of thiophene-2-carboxylate, indole-2-carbaldehyde and acetophenone provides an expedient route to a series of tetracyclic carbazolothiophene compounds bearing the indole and thiophene rings. Among these samples, 9-benzyl-4-methyl-4-(4-hydroxyphenyl)-10-oxo-4,10-dihydrocarbazolo[2,3-b]thiophene-2-carboxylic acid (18) shows the most potent inhibition against the endothelin-1 induced increase of intracellular calcium ion concentration.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
LS7931227 Thiophene-2-carboxylic acid methyl ester-5-boric acid Thiophene-2-carboxylic acid methyl ester-5-boric acid Price
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