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Carbohydrate-carbohydrate Interaction: Zymosan and Beta-Glucan From Saccharomyces Cerevisiae Bind Mannosylated Glycoconjugates

Carbohydrate-carbohydrate Interaction: Zymosan and Beta-Glucan From Saccharomyces Cerevisiae Bind Mannosylated Glycoconjugates

E V Mikhalchik, S D Shiyan, N V Bovin

Biochemistry (Mosc). 2000 Apr;65(4):494-501.

PMID: 10810189

Abstract:

Zymosan from cell wall of the yeast Saccharomyces cerevisiae was found to interact with synthetic and natural glycoconjugates; mannose-rich glycoprotein N-chains demonstrated the maximal affinity. The carbohydrate-carbohydrate nature of the interaction has been confirmed by the following data: 1) periodate treatment of the zymosan impairs the binding; 2) neither protease nor alkali treatment of the zymosan weaken the binding; 3) beta-glucan from S. cerevisiae, which is the major zymosan component, interacts with glycoconjugates similarly to zymosan. The binding is reversible, Ca2+-dependent, and cooperative; it can be dose-dependently inhibited by saccharides relative to one of the partners of the carbohydrate-carbohydrate interaction.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP58856932	Zymosan A from Saccharomyces cerevisiae		58856-93-2	Price

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