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Carbon Nanomaterials: Biologically Active Fullerene Derivatives

Carbon Nanomaterials: Biologically Active Fullerene Derivatives

Gordana Bogdanović, Aleksandar Djordjević

Srp Arh Celok Lek. Mar-Apr 2016;144(3-4):222-31.

PMID: 27483572

Abstract:

Since their discovery, fullerenes, carbon nanotubes, and graphene attract significant attention of researches in various scientific fields including biomedicine. Nano-scale size and a possibility for diverse surface modifications allow carbon nanoallotropes to become an indispensable nanostructured material in nanotechnologies, including nanomedicine. Manipulation of surface chemistry has created diverse populations of water-soluble derivatives of fullerenes, which exhibit different behaviors. Both non-derivatized and derivatized fullerenes show various biological activities. Cellular processes that underline their toxicity are oxidative, genotoxic, and cytotoxic responses.The antioxidant/cytoprotective properties of fullerenes and derivatives have been considered in the prevention of organ oxidative damage and treatment. The same unique physiochemical properties of nanomaterials may also be associated with potential health hazards. Non-biodegradability and toxicity of carbon nanoparticles still remain a great concern in the area of biomedical application. In this review, we report on basic physical and chemical properties of carbon nano-clusters--fullerenes, nanotubes, and grapheme--their specificities, activities, and potential application in biological systems. Special emphasis is given to our most important results obtained in vitro and in vivo using polyhydroxylated fullerene derivative C₆₀(OH)₂₄.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS71739	Polyhydroxylated fullerenes, water soluble			Price

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