Home
Resources
Publications
Cardiovascular Pharmacodynamics of Donepezil Hydrochloride on the PR and QT Intervals in Patients With Dementia

Cardiovascular Pharmacodynamics of Donepezil Hydrochloride on the PR and QT Intervals in Patients With Dementia

Hirofumi Igeta, Yutaro Suzuki, Misuzu Tajiri, Toshiyuki Someya

Hum Psychopharmacol. 2014 May;29(3):292-4.

PMID: 24615803

Abstract:

Objective:
Although several case reports suggested that donepezil hydrochloride can induce bradycardia or atrioventricular block, the details remain unclear. We implemented a study of the impact of donepezil hydrochloride administration on PR, RR, and QT intervals.
Methods:
The subjects were 18 patients who were diagnosed with either dementia or cognitive disorder (DSM-IV-TR) and were hospitalized between January 2011 and December 2012. After hospitalization, they were treated with donepezil hydrochloride. Clinical parameters and electrocardiograms before and after the administration of donepezil hydrochloride were retrieved from the patients' medical records.
Results:
After the administration of donepezil hydrochloride, the mean PR interval significantly increased from 177.3 ± 30.9 to 186.8 ± 38.4 ms (p<0.001). And the mean RR interval also significantly increased from 850.3 ± 112.5 to 886.7 ± 136.4 ms (p=0.014). The mean difference in the PR interval before and after the administration of donepezil hydrochloride was 9.5 ± 17.1 (range=-21.0-44.0) ms. The QT intervals were unaffected by the administration of donepezil hydrochloride.
Conclusions:
Care should be taken when administering donepezil to patients with atrioventricular block, or patients taking other drugs that can prolong the PR interval. Copyright © 2014 John Wiley & Sons, Ltd.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP120011703-A	Donepezil Hydrochloride		120011-70-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: