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Carrier-free, Water Dispersible and Highly Luminescent Dye Nanoparticles for Targeted Cell Imaging

Carrier-free, Water Dispersible and Highly Luminescent Dye Nanoparticles for Targeted Cell Imaging

Xiaojun Diao, Wei Li, Jia Yu, Xiaojing Wang, Xiujuan Zhang, Yinlong Yang, Feifei An, Zhuang Liu, Xiaohong Zhang

Nanoscale. 2012 Sep 7;4(17):5373-7.

PMID: 22814892

Abstract:

We develop a new strategy of using surface functionalized small molecule organic dye nanoparticles (NPs) for targeted cell imaging. Organic dye (2-tert-butyl-9,10-di(naphthalen-2-yl)anthracene, TBADN) was fabricated into NPs and this was followed by surface modification with an amphipathic surfactant poly(maleic anhydride-alt-1-octadecene)-polyethylene glycol (C18PMH-PEG) through hydrophobic interactions to achieve good water dispersibility and bio-environmental stability. It should be noted that no additional inert materials were added as carriers, thus the dye-loading capacity of the resulting TBADN NPs is obviously higher than those of previously reported carrier-based structures. This would lead to much larger absorption and then much higher brightness. The resulting TBADN NPs possess comparable, if not higher, brightness than CdSe/ZnS quantum dots under the same conditions, with favorable biocompatibility. Significantly, TBADN NPs are readily conjugated with folic acid, and successfully applied in targeted cell imaging. These results show that water dispersible and highly stable organic NPs would be a promising new class of fluorescent probe for bioapplications in cellular imaging and labeling. This strategy may be straightforwardly extended to other organic dyes to achieve water dispersible NPs for cell imaging and drug delivery.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP274905736	TBADN		274905-73-6	Price

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