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Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study

Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study

Liv Kroona, Marléne Isaksson, Camilla Ahlgren, Jakob Dahlin, Magnus Bruze, Gunnar Warfvinge

Acta Derm Venereol. 2018 Nov 5;98(10):938-942.

PMID: 30085320

Abstract:

Carvone (l-carvone), a mint flavour in spearmint oil, is considered a mild skin sensitizer. Carvone-sensitization may be linked to oral/perioral signs and oral lichen planus, but studies are sparse. The prevalence of patch test reactions to carvone and relevant findings from the positive group were investigated. Records for patch-tested patients at the Malmö clinic, for the period 1996 to 2016, were studied. Carvone-positive and carvone-negative patients were compared regarding patch test data from baseline series and dental series. Dental series-tested carvone-positive patients were also compared with a matched group. A total of 147 out of 4,221 referred patients had a positive patch test to carvone. Sensitized patients had higher mean age and were primarily women; 73% had oral signs and 57% had oral lichen. Concomitant patch test reactions to gold, nickel and mercury were common. In the matched group-comparison carvone-positive patients had a higher frequency of oral lichen, but no difference was found in sensitization to gold and mercury.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2244168	(+)-Carvone		2244-16-8	Price

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