0

Cascade Alkylation and Deuteration With Aryl Iodides via Pd/norbornene Catalysis: An Efficient Method for the Synthesis of Congested Deuterium-Labeled Arenes

Lei Guo, Chen Xu, Ding-Chuan Wu, Guang-Qi Hu, Hong-Hai Zhang, Kunlun Hong, Su Chen, Xiang Liu

Chem Commun (Camb). 2019 Jul 18;55(59):8567-8570.

PMID: 31273365

Abstract:

An efficient approach for synthesizing congested deuterium-labeled arenes via cascade alkylation and deuteration with aryl iodides has been disclosed. We found that the adoption of sodium formate-d as a deuterium source is the key for achieving high deuterium incorporation >98%.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP3996154 Sodium formate-d Sodium formate-d 3996-15-4 Price
qrcode