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Case of Endophthalmitis Following Intravitreal Injections of Bevacizumab

Case of Endophthalmitis Following Intravitreal Injections of Bevacizumab

Shinya Komori, Akira Sawada, Tsutomu Oguni, Kiyofumi Mochizuki, Kiyofumi Ohkusu

Clin Ophthalmol. 2010 Jul 30;4:773-5.

PMID: 20689793

Abstract:

Purpose:
We report a case of infectious endophthalmitis that developed after the third intravitreal injection of bevacizumab. The endophthalmitis was caused by Staphylococcus epidermidis.
Methods:
Observational case series.
Results:
This was a case of a 77-year-old man who had received three intravitreal injections of bevacizumab and developed infectious endophthalmitis. Polymerase chain reaction of an aqueous humor sample showed that the endophthalmitis was caused by S. epidermidis. The patient received intravitreal ceftazidime and vancomycin, and subconjunctival injection of vancomycin. After the intravitreal injections he was treated with topical levofloxacin and cefmenoxime hydrochloride, and intravenous cefpirome. Subsequently, the ocular inflammation gradually decreased and his visual acuity remained at 30/200.
Conclusions:
Our findings indicate that endophthalmitis can develop after intravitreal bevacizumab injections. Polymerase chain reaction is useful for differentiation from sterile endophthalmitis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS31041001	Cefmenoxime hydrochloride			Price

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