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Caspase-4 and caspase-5, Members of the ICE/CED-3 Family of Cysteine Proteases, Are CrmA-inhibitable Proteases

Caspase-4 and caspase-5, Members of the ICE/CED-3 Family of Cysteine Proteases, Are CrmA-inhibitable Proteases

S Kamada, Y Funahashi, Y Tsujimoto

Cell Death Differ. 1997 Aug;4(6):473-8.

PMID: 16465268

Abstract:

Proteases of the caspase family are implicated in mammalian apoptosis and constitute a protease cascade. We characterized caspase-4 (TX/ICH-2/ICErelII) and caspase-5 (ICErelIII/TY), which are most closely related to caspase-1 (ICE) among the caspase family. Although overexpression of caspase-4 and caspase-5 induced apoptosis, confirming previous observations, this apoptosis was not inhibited by a caspase-1-specific tetrapeptide inhibitor (Ac-YVAD-CHO), suggesting that caspase-4 and caspase-5 have different substrate specificities from caspase-1 and also that caspase-4- and caspase-5-induced apoptosis is not mediated by caspase-1. CrmA, a cowpox virus-derived caspase-1 inhibitor that prevents apoptosis induced by various stimuli, was cleaved by caspase-4 and caspase-5, and inhibited their proteolytic activity as assessed by cleavage of pro-caspase-3 (pro-CPP32/Yama/apopain). Thus, caspase-4 and caspase-5 are CrmA-inhibitable proteases like caspase-1 and might be involved in apoptosis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4249309	Caspase 4 Inhibitor (ICH-2)			Price

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