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Caspase Inhibition Decreases Cell Death in Regions of Adult Neurogenesis

Caspase Inhibition Decreases Cell Death in Regions of Adult Neurogenesis

Manfred Biebl, Beate Winner, Jürgen Winkler

Neuroreport. 2005 Aug 1;16(11):1147-50.

PMID: 16012338

Abstract:

The generation of new neurons in adult neurogenic regions is paralleled by a high rate of cell death. To further characterize the interplay between generation and removal of new cells, we studied the role of caspase 2 (Nedd 2) and 3 (CPP 32) on the basis of the high expression of these cysteine proteases in neurogenic regions. By injecting the broad spectrum caspase inhibitor BOC-Asp(OMe)-fluoromethyl ketone into the lateral ventricle of adult rats, a 60% ;reduction of terminal deoxynucleotidyl transferase dUTP Nick End Labeling (TUNEL) profiles was observed in all neurogenic regions without changing the number of newly generated cells. These data suggest that inhibiting the caspase activity in vivo decreases the rate of cell death, but has no influence on the generation of new neurons.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP187389533	Boc-Asp(OMe)-fluoromethyl ketone		187389-53-3	Price

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