0

Catalase Is Inhibited by Flavonoids

Justyna Krych, Lidia Gebicka

Int J Biol Macromol. 2013 Jul;58:148-53.

PMID: 23567286

Abstract:

Catalases, heme enzymes, which catalyze decomposition of hydrogen peroxide to water and molecular oxygen, belong to the antioxidant defense system of the cell. In this work we have shown that catalase from bovine liver is inhibited by flavonoids. The inhibition is, at least partially, due to the formation of hydrogen bonds between catalase and flavonoids. In the presence of some flavonoids the formation of unreactive catalase compound II has been detected. The most potent catalase inhibitors among the tested flavonoids have appeared myricetin, epicatechin gallate and epigallocatechin gallate. The relationship between the degree of enzyme inhibition and molecular structure of flavonoids has been analyzed.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AS212979 Catalase from bovine liver Catalase from bovine liver Price
qrcode