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Catalytic Asymmetric Conjugate Allylation of Coumarins

Yulong Kuang, Xiaohua Liu, Lu Chang, Min Wang, Lili Lin, Xiaoming Feng

Org Lett. 2011 Aug 5;13(15):3814-7.

PMID: 21688863

Abstract:

A catalytic asymmetric conjugate allylation was successfully developed to synthesize potential pharmacologically active 4-allyl-2-oxochroman skeletons. A dual activation strategy was employed by using N,N'-dioxide-Yb(OTf)(3) to activate coumarins and using (CuOTf)(2)•C(7)H(8) to activate tetraallyltin via transmetalation, respectively. Good yields and enantioselectivities were obtained under mild conditions.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP7393433 Tetraallyltin Tetraallyltin 7393-43-3 Price
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