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Catalytic Cyclopropanation of Alkenes Using Diazo Compounds Generated in Situ. A Novel Route to 2-arylcyclopropylamines

V K Aggarwal, J de Vicente, R V Bonnert

Org Lett. 2001 Aug 23;3(17):2785-8.

PMID: 11506634

Abstract:

[reaction: see text]. A user-friendly, one-pot process for catalytic cyclopropanation of alkenes from tosylhydrazones is described. The cyclopropanation of N-vinylphthalimide provides a new route to 2-arylcyclopropylamines, and this is exemplified in the efficient synthesis of the HIV-1 reverse transcriptase inhibitor 6.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP3485845 N-Vinylphthalimide N-Vinylphthalimide 3485-84-5 Price
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