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Cathinone, an Active Principle of Catha Edulis, Accelerates Oxidative Stress in the Limbic Area of Swiss Albino Mice

Cathinone, an Active Principle of Catha Edulis, Accelerates Oxidative Stress in the Limbic Area of Swiss Albino Mice

Mohammed M Safhi, Mohammad Firoz Alam, Sohail Hussain, Mohammed Abdul Hakeem Siddiqui, Gulrana Khuwaja, Ibrahim Abdu Jubran Khardali, Rashad Mohammed Al-Sanosi, Fakhrul Islam

J Ethnopharmacol. 2014 Oct 28;156:102-6.

PMID: 25153022

Abstract:

Ethnopharmacological relevance:
Cathinone hydrochloride is an active principle of the khat plant (Catha edulis) that produces pleasurable and stimulating effects in khat chewers. To the best of our knowledge no data of cathinone on oxidative stress in limbic areas of mice is available. This is the first study of cathinone on oxidative stress in limbic areas of the brain in Swiss albino male mice.
Materials and methods:
The animals were divided into four groups. Group-I was the control group and received vehicle, while groups-II to IV received (-)-cathinone hydrochloride (0.125, 0.25 and 0.5 mg/kg body wt., i.p.) once daily for 15 days.
Results:
The level of lipid peroxidation (LPO) was elevated dose-dependently and was significant (p<0.05, p<0.01) with doses of 0.25 and 0.5mg/kg body wt. of cathinone as compared to control group. In contrast, the content of reduced glutathione (GSH) was decreased significantly (p<0.01, p<0.001) with doses of 0.25 and 0.5mg/kg body wt. of cathinone as compared to control group. The activity of antioxidant enzymes (GPx, GR, GST, CAT, and SOD) was also decreased dose-dependently: the decreased activity of GPx, GR, catalase and SOD was significant with doses of 0.25 and 0.5 mg of cathinone as compared to control group, while the activity of GST was decreased dose-dependently and was significant with 0.5mg of cathinone as compared to control group.
Conclusions:
The results indicate that the cathinone generated oxidative stress hampered antioxidant enzymes, glutathione and lipid peroxidation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP16735196	Cathinone hydrochloride		16735-19-6	Price

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