Home
Resources
Publications
Cation Effects on Phosphatidic Acid Monolayers at Various pH Conditions

Cation Effects on Phosphatidic Acid Monolayers at Various pH Conditions

Ting Zhang, Matthew G Cathcart, Andrew S Vidalis, Heather C Allen

Chem Phys Lipids. 2016 Oct;200:24-31.

PMID: 27335336

Abstract:

The impact of pH and cations on phase behavior, stability, and surface morphology for dipalmitoylphosphatidic acid (DPPA) monolayers was investigated. At pH<10, DPPA monolayers on water are predominantly populated by neutral species and display the highest packing density. Cations are found to expand and stabilize the monolayer in the following order of increasing magnitude at pH 5.6: Na+>K+∼Mg2+>Ca2+. Additionally, cation complexation is tied to the pH and protonation state of DPPA, which are the primary factors controlling the monolayer surface behavior. The binding affinity of cations to the headgroup and thus deprotonation capability of the cation, ranked in the order of Ca2+>Mg2+>Na+>K+, is found to be well explained by the law of matching water affinities. Nucleation of surface 3D lipid structures is observed from Ca2+, Mg2+, and Na+, but not from K+, consistent with the lowest binding affinity of K+. Unraveling cation and pH effects on DPPA monolayers is useful in further understanding the surface properties of complex systems such as organic-coated marine aerosols where organic films are directly influenced by the pH and ionic composition of the underlying aqueous phase.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4247419	1,2-Dipalmitoyl-sn-glycero-3-phosphate sodium salt			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: