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Ceforanide: In Vitro and Clinical Evaluation

Ceforanide: In Vitro and Clinical Evaluation

K H Burch, D Pohlod, L D Saravolatz, T Madhavan, D Kiani, E L Quinn, R Del Busto, J Cardenas, E J Fisher

Antimicrob Agents Chemother. 1979 Sep;16(3):386-91.

PMID: 507795

Abstract:

Ceforanide, a new cephalosporin antibiotic with a long half-life (3 h), can be administered twice daily. We evaluated its antimicrobial activity, pharmacology, and clinical efficacy. Twenty-seven patients with infections due to susceptible organisms received ceforanide, 0.5, 1, or 2 g, intramuscularly or intravenously every 12 h for 6 to 28 days. In vitro studies with the clinical isolates from 27 patients treated plus 263 additional isolates showed that ceforanide was active against cephalothin-susceptible gram-positive and gram-negative microorganisms. In addition, ceforanide inhibited 65% of cephalothin-resistant Escherichia coli and 65% of Enterobacter spp. at

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP60925613	Ceforanide		60925-61-3	Price

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