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Cellulose Acetate butyrate/poly(caprolactonetriol) Blends: Miscibility, Mechanical Properties, and in Vivo Inflammatory Response

Luiz A Kanis, Ellen L Marques, Karine M Zepon, Jefferson R Pereira, Saulo Pamato, Marcelo T de Oliveira, Lucinéia G Danielski, Fabricia C Petronilho

J Biomater Appl. 2014 Nov;29(5):654-61.

PMID: 25015652

Abstract:

This study reports the results of the characterization of cellulose acetate butyrate and polycaprolactone-triol blends in terms of miscibility, swelling capacity, mechanical properties, and inflammatory response in vivo. The cellulose acetate butyrate film was opaque and rigid, with glass transition (T g ) at 134℃ and melting temperature of 156℃. The cellulose acetate butyrate/polycaprolactone-triol films were transparent up to a polycaprolactone-triol content of 60%. T g of the cellulose acetate butyrate films decreased monotonically as polycaprolactone-triol was added to the blend, thus indicating miscibility. FTIR spectroscopy revealed a decrease in intramolecular hydrogen bonding in polycaprolactone-triol, whereas no hydrogen bonding was observed between cellulose acetate butyrate and -OH from polycaprolactone-triol. The increase in polycaprolactone-triol content in the blend decreased the water uptake. An increase in polycaprolactone-triol content decreased the modulus of elasticity and increased the elongation at break. A cellulose acetate butyrate/polycaprolactone-triol 70/30 blend implanted in rats showed only an acute inflammatory response 7 days after surgery. No change in inflammation mediators was observed.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP37625562 Polycaprolactone triol Polycaprolactone triol 37625-56-2 Price
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