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Central Effects of Cromoglycate Sodium Salt in Rats Treated With Lipopolysaccharide

Central Effects of Cromoglycate Sodium Salt in Rats Treated With Lipopolysaccharide

F Nava, A P Caputi

Eur J Pharmacol. 1999 Feb 19;367(2-3):351-9.

PMID: 10079011

Abstract:

In 24-h water- and food-deprived rats, we have evaluated the effects of cromoglycate sodium salt, an inhibitor of the mast cell degranulation with anti-inflammatory and membrane-stabilizating activity, on the central effects induced by Escherichia coli lipopolysaccharide (LPS). Intraperitoneal (i.p.) injection of LPS (0.25, 0.50 and 1 mg/kg) induced a dose-dependent inhibition of water and food intake, fever, reduction in locomotor activity as well as increased anxiety levels. All these LPS effects were antagonized by a prior intracerebroventricular (i.c.v.) injection of cromoglycate sodium salt (100, 150 and 200 microg/rat). Our findings suggest that peripheral LPS administration may activate brain mast cells and indicate an involvement of these cells in brain pathophysiology.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP15826376-B	Cromolyn sodium salt		15826-37-6	Price

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