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Cerium and Yttrium Oxide Nanoparticles Are Neuroprotective

Cerium and Yttrium Oxide Nanoparticles Are Neuroprotective

David Schubert, Richard Dargusch, Joan Raitano, Siu-Wai Chan

Biochem Biophys Res Commun. 2006 Mar 31;342(1):86-91.

PMID: 16480682

Abstract:

The responses of cells exposed to nanoparticles have been studied with regard to toxicity, but very little attention has been paid to the possibility that some types of particles can protect cells from various forms of lethal stress. It is shown here that nanoparticles composed of cerium oxide or yttrium oxide protect nerve cells from oxidative stress and that the neuroprotection is independent of particle size. The ceria and yttria nanoparticles act as direct antioxidants to limit the amount of reactive oxygen species required to kill the cells. It follows that this group of nanoparticles could be used to modulate oxidative stress in biological systems.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP12014447	Aluminum cerium oxide		12014-44-7	Price

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