Home
Resources
Publications
CGK733 Enhances Multinucleated Cell Formation and Cytotoxicity Induced by Taxol in Chk1-deficient HBV-positive Hepatocellular Carcinoma Cells

CGK733 Enhances Multinucleated Cell Formation and Cytotoxicity Induced by Taxol in Chk1-deficient HBV-positive Hepatocellular Carcinoma Cells

Huan Wang, Bin Zuo, Haibin Wang, Laifeng Ren, Peng Yang, Ming Zeng, Dan Duan, Cong Liu, Mingyuan Li

Biochem Biophys Res Commun. 2012 May 25;422(1):103-8.

PMID: 22564734

Abstract:

Hepatocellular carcinoma (HCC) is one of the most deadly human cancers. Chronic hepatitis B virus (HBV) infection is one of the predominant risk factors associated with the development of HCC and complicates the treatment of HCC. In this study, we demonstrate that a HBV-positive HCC cell line HepG2.2.15, was more resistant to chemotherapy agents than its parental HBV-negative cell line HepG2. HBV-positive HCC cells exhibited defective Chk1 phosphorylation and increased chromosomal instability. CGK733, a small molecule inhibitor reportedly targeting the kinase activities of ATM and ATR, significantly enhanced taxol-induced cytotoxicity in HBV-positive HepG2.2.15 cells. The mechanism lies in CGK733 triggers the formation of multinucleated cells thus promotes the premature mitotic exit of taxol-induced mitotic-damaged cells through multinucleation and mitotic catastrophe in HBV-positive HepG2.2.15 cells. These results suggest that CGK733 could potentially reverse the taxol resistance in HBV-positive HCC cells and may suggest a novel strategy to treat HBV-infected HCC patients.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4242694	CGK733			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: