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Characteristics of New Monomolecular Chimeric T-cell Receptors to Carcinoembryonic Antigen

Characteristics of New Monomolecular Chimeric T-cell Receptors to Carcinoembryonic Antigen

V K Bozhenko, E I Shramova, A M Shishkin, A V Ivanov, E V Khokhlova, Yu S Lebedin, A N Shkoporov

Bull Exp Biol Med. 2013 Nov;156(1):165-71.

PMID: 24319717

Abstract:

We described two original genetic constructs encoding chimeric monomolecular T-cell receptors, where the effector T-cell receptor fragment was linked with the antigen-recognizing part consisting of two variable fragments of two different antibodies to carcinoembryonic antigen. Following transfection, these receptors were expressed on the cell surface and bound carcinoembryonic antigen. Human peripheral blood lymphocytes transfected with the above constructs demonstrated high cytotoxic activity against HCT116 cells expressing carcinoembryonic antigen.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42414842	Carcinoembryonic Antigen human			Price

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