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Characteristics, Properties and Analytical Methods for Determination of Dropropizine and Levodropropizine: A Review

Characteristics, Properties and Analytical Methods for Determination of Dropropizine and Levodropropizine: A Review

Anna Karolina Mouzer da Silva Machado, Marina Cardoso Nemitz, Vitor Todeschini, Maximiliano da Silva Sangoi

Crit Rev Anal Chem. 2019 Dec 9;1-9.

PMID: 31814444

Abstract:

Dropropizine is a peripheral antitussive drug that acts by inhibiting cough reflex through its action on the peripheral receptors and their afferent conductors. It is marketed in a racemic form or its pure enantiomer called levodropropizine and both are available worldwide in various drug dosage formulations such as tablets, sirup and oral solution. Due to the widespread use of antitussives in the clinic it is necessary to develop efficient analytical methodologies for quality control and also for pharmacokinetic, bioavailability and bioequivalence studies. This review presents a survey of the characteristics, properties and analytical methods used for drug determination, being carried out through scientific articles as well as in official compendia. From the analyzed studies, the majority reports the use of HPLC/UV techniques for drug determination, but also spectrophotometric UV/Vis methods as well as gas chromatography, and voltammetric, potentiometric and conductometric titration methods. In addition, the methodologies addressed the determination of dropropizine or levodropropizine in different types of matrices such as raw material, pharmaceutical formulations, plasma and urine. Despite the extensive clinical use of dropropizine, data from this review evidenced a still limited number of studies dealing with analytical methods for its determination in different matrices, which may be of concern since the applicability of these methods is important for quality assurance, efficacy and safety of the medicine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP17692318	(±)-Dropropizine		17692-31-8	Price

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