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Characterization of [3H]GR 113808 Binding to 5-HT4 Receptors in Brain Tissues From Patients With Neurodegenerative Disorders

E H Wong, G P Reynolds, D W Bonhaus, S Hsu, R M Eglen

Behav Brain Res. 1996;73(1-2):249-52.

PMID: 8788512

Abstract:

[3H]GR 113808 binding studies in guinea-pig brain tissue revealed a temperature dependency and pharmacological specificity consistent with labelling of a 5-HT4 receptor. Detailed comparison of competition data between brain regions from human and guinea-pig suggest minor differences in the rank order of affinity. Studies in brain tissue from patients with Alzheimer's Huntington's and Parkinson's disease have revealed specific deficits in 5-HT4 receptor densities.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP144625514 GR 113808 GR 113808 144625-51-4 Price
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