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Characterization of an Intravenous Lipopolysaccharide Inflammation Model in Broiler Chickens

Characterization of an Intravenous Lipopolysaccharide Inflammation Model in Broiler Chickens

S De Boever, S Croubels, E Meyer, S Sys, R Beyaert, R Ducatelle, P De Backer

Avian Pathol. 2009 Oct;38(5):403-11.

PMID: 19937527

Abstract:

Intravenous administration of lipopolysaccharide (LPS) from Escherichia coli O127:B8 at a dose of 1,500,000 u/kg body weight evoked a hypothermic response followed by a fever phase in 5-week-old broiler chickens. The hypothermic phase coincided with a severe decrease in blood pressure. We assume that this decrease in blood pressure is, at least partly, responsible for the hypothermic phase of the body temperature curve. LPS administration also caused a decrease in circulating white blood cells. The heterophils were predominantly sequestered in the lungs. In LPS-treated chickens, far more apoptotic leukocytes were present in the circulation, compared with control chickens. The molecular players responsible for the LPS-induced inflammatory response could be TL1A, IL-1beta and IL-6, since a slight increase in their mRNA levels in white blood cells was already seen 1 h after LPS administration. In accordance with these observations, the levels of secreted IL-6 were maximal 3 h after LPS administration. These parameters characterize this LPS-induced inflammation model in broiler chickens.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS7413114	Lipopolysaccharides from Escherichia coli O127:B8			Price

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