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Chasteberry

PMID: 30000866

Abstract:

Chasteberry (Vitex agnus-castus) is the fruit (berries) from the chaste tree. The berries contain essential oils (e.g., limonene, sabinene, 1,8-cineole [eucalyptol]), iridoid glycosides (e.g., agnoside, aucubin), diterpines (e.g., vitexilactone, rotundifuran), and flavonoids (e.g., apigenin, castican, orientin, isovitexin). Chasteberry is often used for irregularities of the menstrual cycle, infertility, premenstrual complaints, and cyclical breast pain.[1][2] Some constituents, possibly the diterpene clerodadienols, bind to dopamine D2 receptors in the pituitary.[3] In low doses, chasteberry increases serum prolactin and it is a purported galactogogue;[4][5][6] however, no scientifically valid clinical trials support this use and galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[7] Some evidence indicates that high doses of chasteberry decrease serum prolactin and might decrease lactation.[8] It has been used to decrease breastmilk oversupply in Persian traditional medicine.[9]
In general, chasteberry is well tolerated. The most frequent adverse events are nausea, headache, gastrointestinal disturbances, menstrual disorders, acne, pruritus, and erythematous rash; however, all are mild and reversible. Among 352 nursing mothers given chasteberry tincture, 15 cases of pruritus, exanthema, urticaria, and some cases of early menstrual period occurred. Because of concerning safety data and possible lactation suppression, chasteberry should be avoided during lactation.[10]
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Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP479981-A Aucubin Aucubin 479-98-1 Price
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