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Chelerythrine Chloride Induces Rapid Polymorphonuclear Leukocyte Apoptosis Through Activation of caspase-3

Chelerythrine Chloride Induces Rapid Polymorphonuclear Leukocyte Apoptosis Through Activation of caspase-3

J F Sweeney, P K Nguyen, K B Atkins, D B Hinshaw

Shock. 2000 Jun;13(6):464-71.

PMID: 10847634

Abstract:

Polymorphonuclear leukocytes (PMN) play a primary role in the initiation and propagation of inflammatory responses. PMN apoptosis is a major mechanism associated with the resolution of inflammatory reactions. Understanding mechanisms associated with PMN apoptosis will be of critical value in the development of novel pharmacological treatment strategies for local and/or systemic inflammatory disorders. The present study demonstrates that chelerythrine chloride induces human PMN to undergo rapid and synchronous progression into the apoptotic process via a PKC-independent mechanism. The appearance of the morphological features of apoptosis in chelerythrine-treated PMN is preceded by a significant upregulation in caspase-3 activity. GM-CSF (a cytokine that protects PMN in several models of PMN apoptosis) does not protect PMN from chelerythrine chloride-induced apoptosis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3895929-B	Chelerythrine chloride		3895-92-9	Price

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