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Chemical Constituents From the Stems of Gymnema Sylvestre

Chemical Constituents From the Stems of Gymnema Sylvestre

Yue Liu, Tun-Hai Xu, Man-Qi Zhang, Xue Li, Ya-Juan Xu, Hong-Yu Jiang, Tong-Hua Liu, Dong-Ming Xu

Chin J Nat Med. 2014 Apr;12(4):300-4.

PMID: 24863357

Abstract:

Aim:
To study the chemical constituents of stems of Gymnema sylvestre (Retz.) Schult.
Methods:
Chromatographic techniques using silica gel, C18 reversed phase silica gel, and prep-HPLC were used. The structures were elucidated on the basis of MS and spectroscopic analysis (1D and 2D NMR), as well as chemical methods.
Results:
Seven compounds were isolated and their structures were elucidated as conduritol A (1), stigmasterol (2), lupeol (3), stigmasterol-3-O-β-D-glucoside (4), the sodium salt of 22α-hydroxy-longispinogenin-3-O-β-D-glucopyranosyl-(1→3)-β-D-glu-curono-pyranosyl-28-O-α-L-rhamnopyranoside (5), oleanolic acid-3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (6), and the sodium salt of 22α-hydroxy-longispinogenin 3-O-β-D-glucuronopyranosyl-28-O-α-L-rhamnopyranoside (7). The inhibition activities of compounds 1, 5-7 on non-enzymatic glycation of protein in vitro were evaluated.
Conclusion:
Compound 7 is a new triterpenoid saponin. It was shown that compounds 1, 5-7 have weak inhibition activities for non-enzymatic glycation of protein in vitro.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LPLC81602	C18-Reversed phase silica gel			Price

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