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Chemical Inhibitors: The Challenge of Finding the Right Target

David Calligaris, Daniel Lafitte

Chem Biol. 2011 May 27;18(5):555-7.

PMID: 21609834

Abstract:

A paper in this issue of Chemistry & Biology shows that the diaryl oxazole compound UA62784 that targets pancreatic cancer cells interacts with tubulin near the colchicine binding site (Tcherniuk et al., 2011). These findings differ from previous observations, highlighting the challenges of identifying the biological target for chemical inhibitors.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP313367929 UA62784 UA62784 313367-92-9 Price
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