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Chemical modification of Bombyx mori silk fibers with vinyl groups for thiol-ene click chemistry

Chemical modification of Bombyx mori silk fibers with vinyl groups for thiol-ene click chemistry

Xiaoning Zhang, Jianwei Liang, Zhenyu Chen, Carrie Donley, Yuling Liu, Guotao Cheng

BMC Chem. 2019 Sep 10;13(1):114.

PMID: 31517313

Abstract:

Natural Bombyx mori silk fibroin (SF) fibers were modified with 2-methacryloyloxyethyl isocyanate (MOI) first for the introduction of vinyl groups. Then, 1H,1H,2H,2H-perfluorodecanethiol was grafted onto the SF fibers via thiol-ene click chemistry using ultraviolet light. The formations of MOI-modified and PFDT-grafted SF fibers were analyzed using Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, respectively. The morphology of samples was also revealed by a scanning electron microscope. In addition, differential scanning calorimetry results demonstrated that SF fibers did not show significant change in thermal behavior, regardless of the chemical modification. To confirm the cytotoxicity of the prepared SF fibers, MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay was performed, and no toxicity was observed with PFDT-grafted SF fibers. The results also showed that PFDT-grafted SF fibers exhibited good antifouling properties when Chlorella vulgaris (C. vulgaris) was selected as a model for algal cells adhesion experiment.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP34143743	1H,1H,2H,2H-Perfluorodecanethiol		34143-74-3	Price

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