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Chemical Stability of Ondansetron Hydrochloride With Other Drugs in Admixtures via Parenteral; A Review

Chemical Stability of Ondansetron Hydrochloride With Other Drugs in Admixtures via Parenteral; A Review

Gabriel Estan-Cerezo, Inmaculada Jiménez-Pulido, Francisco José Rodríguez Lucena, Carmen Matoses Chirivella, Leticia Soriano-Irigaray, Andrés Navarro-Ruiz

Farm Hosp. 2017 Sep 1;41(5):625-629.

PMID: 28847252

Abstract:

Objective:
This review was prepared to offer the most complete information about the use of ondansetron in parenteral admixtures with other drugs.
Method:
The search was done from September 2016 to April 2017 by using electronic databases Stabilis® and Micromedex® solutions, Medline/PubMed and Scholar Google searching publications about ondansetron stability in parenteral infusion when is administered by itself or with other medication.
Results:
49 studies are included with a total of 53 drugs. 15 drugs were found compatible administered with ondansetron in a clinical routine concentration range in intravenous administration. Also, four ternary blends were found compatible and another one was incompatible. Otherwise, 38 drugs were found incompatible.
Discussion:
Compatibility of ondansetron offers a broad number of options to be used to avoid nausea and vomiting symptoms in patients with other concomitant medication.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP103639049-A	Ondansetron hydrochloride		103639-04-9	Price

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