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Chemo-enzymatic Synthesis of Equisetin

Chemo-enzymatic Synthesis of Equisetin

Xiaojun Li, Qingfei Zheng, Jun Yin, Wen Liu, Shuanhu Gao

Chem Commun (Camb). 2017 Apr 25;53(34):4695-4697.

PMID: 28401214

Abstract:

We here report that the biosynthesis of equisetin, a fungal tetramate natural product with potent anti-infectious activity, relies on Fsa2, a Diels-Alderase that constructs the trans-decalin system of the molecule in a stereo-selective manner. This finding led to the development of a concise chemo-enzymatic route toward the synthesis of equisetin, which involves facile preparation of a linear polyene precursor via 7-steps and Fsa2 activity for equisetin maturation through an intramolecular Diels-Alder reaction, thus exemplifying the significance of the combination of chemical and biological methods to achieve structurally complex cyclic natural products and their derivatives.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP57749436	Equisetin		57749-43-6	Price

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