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Chemopreventive Potential of Vanillic Acid Against 7,12-dimethylbenz(a)anthracene-induced Hamster Buccal Pouch Carcinogenesis

Chemopreventive Potential of Vanillic Acid Against 7,12-dimethylbenz(a)anthracene-induced Hamster Buccal Pouch Carcinogenesis

Anbalagan Vinoth, Raju Kowsalya

J Cancer Res Ther. Oct-Dec 2018;14(6):1285-1290.

PMID: 30488845

Abstract:

Objectives:
The aim of this study was to evaluate the chemopreventive potential of vanillic acid against 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch oral carcinogenesis.
Materials and methods:
Determine the tumor incidence, tumor volume and burden, assessment of the status of Phase I and Phase II detoxification enzymes were measured in the liver and buccal mucosa of hamsters using specific colorimetric methods.
Results:
One hundred percent tumor formation was observed in DMBA alone treated hamsters. Phase I and Phase II detoxification enzymes status were significantly altered DMBA-induced oral carcinogenesis. Vanillic acid (200 mg/kg bw p.o) significantly restored the biochemical variables of liver and buccal mucosa in DMBA + vanillic acid treated hamsters to near normal range compared with DMBA alone treated hamsters.
Conclusion:
The present study thus shows chemopreventive potential of vanillic acid in DMBA-induced hamster buccal pouch carcinogenesis. Vanillic acid improves the phase I and phase II detoxification enzymes in DMBA treated hamsters.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP121346	Vanillic acid		121-34-6	Price

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