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Chemotactic and Phagocytic Responses of Human Alveolar Macrophages to Activated Complement Components

S W Richards, P K Peterson, H A Verbrugh, R D Nelson, D E Hammerschmidt, J R Hoidal

Infect Immun. 1984 Feb;43(2):775-8.

PMID: 6693176

Abstract:

Human alveolar macrophages (AMs) migrated toward and aggregated to C5a but not toward C5a-deficient serum. Human AMs from cigarette smokers migrated significantly farther than did AMs from nonsmokers. Human AMs phagocytized Escherichia coli opsonized with activated C3. Immunoglobulin G was not required for phagocytosis. Human AMs demonstrate chemotaxis and aggregation to C5a. Further, human AMs can phagocytize bacteria coated with activated C3.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR4241066 Complement C5 deficient serum human Complement C5 deficient serum human Price
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