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Chiral Separation by NACE Using Polyol Derivative-Boric Acid Complexes

Lijuan Wang, Xu Hou, Fan Zhang, Ying Liu, Yimeng Ren, Hongyuan Yan

Methods Mol Biol. 2019;1985:383-389.

PMID: 31069747

Abstract:

Nonaqueous capillary electrophoresis (NACE) is an effective method for chiral separation. Many polyol derivatives (e.g., D-(+)-xylose, lactobionic acid, diacetone-D-mannitol, L-sorbose, and D-gluconic acid δ-lactone) can react with boric acid in methanol to produce polyol derivative-boric acid complexes which can be utilized as chiral selectors of enantioseparations. The enantiomers of more than a dozen basic analytes can be resolved under the optimized NACE using these chiral selectors.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP90802 D-(+)-Gluconic acid δ-lactone D-(+)-Gluconic acid δ-lactone 90-80-2 Price
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