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Chlorhexidine Digluconate Effects on Planktonic Growth and Biofilm Formation in Some Field Isolates of Animal Bacterial Pathogens

Chlorhexidine Digluconate Effects on Planktonic Growth and Biofilm Formation in Some Field Isolates of Animal Bacterial Pathogens

Azizollah Ebrahimi, Majid Hemati, Saeed Habibian Dehkordi, Shahab Bahadoran, Sheida Khoshnood, Shahin Khubani, Mahdi Dokht Faraj, Reza Hakimi Alni

Jundishapur J Nat Pharm Prod. 2014 Apr 14;9(2):e14298.

PMID: 24872940

Abstract:

Background:
To study chlorhexidine digluconate disinfectant effects on planktonic growth and biofilm formation in some bacterial field isolates from animals.
Objectives:
The current study investigated chlorhexidine digluconate effects on planktonic growth and biofilm formation in some field isolates of veterinary bacterial pathogens.
Materials and methods:
Forty clinical isolates of Escherichia coli, Salmonella serotypes, Staphylococcus. aureus and Streptococcus agalactiae (10 isolates for each) were examined for chlorhexidine digluconate effects on biofilm formation and planktonic growth using microtiter plates. In all of the examined strains in the presence of chlorhexidine digluconate, biofilm development and planktonic growth were affected at the same concentrations of the disinfectant.
Results:
Chlorhexidine digluconate inhibited the planktonic growth of different bacterial species at sub-MICs. But they were able to induce biofilm development of the E. coli, Salmonella spp., S. aureus and Str. agalactiae strains.
Conclusions:
Bacterial resistance against chlorhexidine is increasing. Sub-MIC doses of chlorhexidine digluconate can stimulate the formation of biofilm strains.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP18472510	Chlorhexidine digluconate		18472-51-0	Price

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