Home
Resources
Publications
Chlorobutanol, a Preservative of Desmopressin, Inhibits Human Platelet Aggregation and Release in Vitro

Chlorobutanol, a Preservative of Desmopressin, Inhibits Human Platelet Aggregation and Release in Vitro

S L Chen, W C Yang, T P Huang, S A Wann, C M Teng

Thromb Haemost. 1990 Nov 30;64(3):473-7.

PMID: 2096493

Abstract:

Therapeutic preparations of desmopressin for parenteral use contain the preservative chlorobutanol (5 mg/ml). We show here that chlorobutanol is a potent inhibitor of platelet aggregation and release. It exhibited a significant inhibitory activity toward several aggregation inducers in a concentration- and time-dependent manner. Thromboxane B2 formation, ATP release, and elevation of cytosolic free calcium caused by collagen, ADP, epinephrine, arachidonic acid and thrombin respectively were markedly inhibited by chlorobutanol. Chlorobutanol had no effect on elastase-treated platelets and its antiplatelet effect could be reversed. It is concluded that the antiplatelet effect of chlorobutanol is mainly due to its inhibition on the arachidonic acid pathway but it is unlikely to have a nonspecific toxic effect. This antiplatelet effect of chlorobutanol suggests that desmopressin, when administered for improving hemostasis, should not contain chlorobutanol as a preservative.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6001645	1,1,1-Trichloro-2-methyl-2-propanol hemihydrate		6001-64-5	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: