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Chlorocardicin, a Monocyclic Beta-Lactam From a Streptomyces Sp. I. Discovery, Production and Biological Activities

Chlorocardicin, a Monocyclic Beta-Lactam From a Streptomyces Sp. I. Discovery, Production and Biological Activities

L J Nisbet, R J Mehta, Y Oh, C H Pan, C G Phelen, M J Polansky, M C Shearer, A J Giovenella, S F Grappel

J Antibiot (Tokyo). 1985 Feb;38(2):133-8.

PMID: 3922933

Abstract:

Chlorocardicin is a new monocyclic beta-lactam produced by a Streptomyces sp. It is structurally related to nocardicin A but differs in having a m-chloro substituent on the p-hydroxyphenylglycine unit. The biological activity of chlorocardicin was similar to nocardicin A but the former showed less antagonism in complex media. Moderate in vitro activity was observed against Enterobacteriaceae and Pseudomonas aeruginosa. Chlorocardicin showed low activity against Staphylococcus aureus whereas nocardicin A was inactive. Both compounds were shown to be strongly potentiated by antibiotics that inhibit peptidoglycan biosynthesis and were antagonized by selected L- and D-amino acids.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS741330	Peptidoglycan from Streptomyces sp.			Price

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